Toluene → HCID 71766905, compound

Participants

Reaction Steps

To 10 minutes ice-bath cooled and stirred solution of ethylenediamine (0.29 ml), trimethylaluminum (2M heptane sol, 2.2 ml) and toluene (10 ml) was added the mixture of methyl 7-bromoisochroman-1-carboxylate (0.5 g) and toluene (10 ml) and the reaction mixture was refluxed for 6 hrs. Water (2 ml), methanol (5 ml) and DCM (5 ml) were added, mixture refluxed for 15 min and participate was filtered off. Organics were evaporated and the title compound (0.38 g) was isolated with the separation method D (2-methoxy-2-methylpropane/MeOH).

Provenance & Evidence