Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Allyltributylstannane | HCID 90628 | — |
| Reactant | HCID 71766904 | HCID 71766904 | — |
| Catalyst | HCID 178418851 | HCID 178418851 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 71766909 | HCID 71766909 | — |
Reaction Steps
To a mixture of 2-(5-chloroisochroman-1-yl)-4,5-dihydro-1H-imidazole (50 mg), allyltributyltin (69.9 mg), CsF (70.6 mg) and bis(tri-t-butylphosphine)palladium (3.24 mg) were added dioxane (2 ml) and DMF (0.5 ml). The reaction mixture was degassed with N2 and heated in a microwave oven for 30 min at 160° C. The title compound was purified by applying methods F and G. (Yield 5.8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09249127B2 |
|---|
| Source dataset | uspto-grants-2016_02 |
|---|
| ORD ID | ord-a082414441f0435fa7cac4e605c88aed |
|---|
| Source note | uspto-grants-2016_02 |
|---|
