HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1771411Generated: November 4, 2026
Dichloromethane → 2-(5-Ethylisochroman-1-yl)-4,5-dihydro-1H-imidazole
https://huagongshe.com/reaction/1771411
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Ethylboronic acid | HCID 521157 | — |
| Reactant | 2-(5-bromoisochroman-1-yl)-4,5-dihydro-1H-imidazole | HCID 71766908 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(5-Ethylisochroman-1-yl)-4,5-dihydro-1H-imidazole | HCID 71766910 | — |
Reaction Steps
To a mixture of 2-(5-bromoisochroman-1-yl)-4,5-dihydro-1H-imidazole (100 mg), ethylboronic acid (56.2 mg), (1,1′-bis(diphenylphosphino)ferrocene)dichloropalladium(II), complex with CH2Cl2 (1:1) (13 mg) and CsF (108 mg) was added dioxane (4 ml) and DMF (1 ml). The mixture was degassed with N2 and heated in a microwave oven for 30 min at 100° C. and 30 min at 150° C. The title compound was purified by separation methods J and G. (Yield 6.1 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09249127B2 |
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| Source dataset | uspto-grants-2016_02 |
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| ORD ID | ord-5a42abff884a4d3f8c4eeb9c278a0cda |
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| Source note | uspto-grants-2016_02 |
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