HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Tributylstannyl)methanol → (1-(4,5-Dihydro-1H-imidazol-2-yl)isochroman-5-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Tributylstannyl)methanol | HCID 4193593 | — |
| Reactant | 2-(5-bromoisochroman-1-yl)-4,5-dihydro-1H-imidazole | HCID 71766908 | — |
| Product | (1-(4,5-Dihydro-1H-imidazol-2-yl)isochroman-5-yl)methanol | HCID 71767060 | — |
Reaction Steps
The title compound was prepared from 2-(5-bromoisochroman-1-yl)-4,5-dihydro-1H-imidazole (50 mg) and (tributylstannyl)methanol (86 mg) by using tetrakis(triphenyl-phosphine)palladium (10.28 mg) as catalyst, and the procedure of synthesis method C and separation methods F and G. (Yield 6.2 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249127B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-ceaa6c2a00dd4123ab46110c52170bf6 |
| Source note | uspto-grants-2016_02 |