Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3,4,7,8-Tetramethyl-1,10-phenanthroline | HCID 74265 | — |
| Reactant | HCID 77230653 | HCID 77230653 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 89851692 | HCID 89851692 | — |
Reaction Steps
The mixture of ethyl 5-bromoisochroman-1-carboxylate (1.0 g, synthesis methods A1 and A2), cesium carbonate (4.57 g), 3,4,7,8-tetramethyl-1,10-phenanthroline (332 mg), copper (I) iodide (134 mg) and ethanol (10 ml) was heated in microwave reactor at 160° C. Methanol was evaporated and the title compound was isolated and purified with separation method B. (Yield 400 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09249127B2 |
|---|
| Source dataset | uspto-grants-2016_02 |
|---|
| ORD ID | ord-e3ed47cfbcf84cc5ace2c397c11cdb5f |
|---|
| Source note | uspto-grants-2016_02 |
|---|
