Aluminum(III) Chloride → HCID 117925532, compound

Participants

Reaction Steps

The solution of ethyl 2-acetoxy-2-(2-methoxyphenethoxy)acetate (12.3 g) in dichloromethane (415 ml) at −20° C. was treated with AlCl3 (5.5 g), and stirred for 1 hr. AlCl3 (5.5 g) was added to the solution and stirred for 3.5 hrs, pours into ice-water (400 ml). Separation method A was applied, followed by distillation (1-2 mbar/120-130° C.) of the crude product to yield ethyl 5-methoxyisochroman-1-carboxylate (5.1 g).

Provenance & Evidence