Dimethylformamide → HCID 71767643, compound

Participants

Reaction Steps

The mixture of NaH (0.39 g), (3R)-ethyl 5-ethyl-3-methylisochroman-1-carboxylate (0.6 g) and DMF (7 ml) was stirred for 2 hrs in ice-bath temperature. Iodomethane (1.5 ml) was added and the mixture was stirred at ambient temperature for 16 hrs. The intermediate (3R)-ethyl 5-ethyl-1,3-dimethylisochroman-1-carboxylate (0.5 g) was purified with separation method A and the title compound was synthesized using the procedure of synthesis method A step 3 and separation method E (EtOAc/DCM/triethyl amine 10/20/1). (Yield 0.06 g).

Provenance & Evidence