Methanol → HCID 89851731, compound

Participants

Reaction Steps

To a solution of 4,4,4-trifluoro-1-(2-methoxyphenyl)butan-2-one (6 g, 25.8 mmol, synthesized as in example 52, step 1) in MeOH (100 ml) was added NaBH4 (1.47 g, 38.7 mmol) at 0° C. and stirred for 1 h at RT. Then the reaction mixture was quenched with MeOH and concentrated under reduced pressure to afford crude compound. The title compound was purified by separation methods A, E and H. Yield (1.7 g). The enantiomer showed up at tr=12.8 min with Chiralpak 1A (4.6×250 mm) 5μ, hexane:2-PrOH:TFA (90:10:0.1), 1 ml/min.

Provenance & Evidence