反应详情

温度

120 °C

A mixture of 6-hydroxynaphthalen-2-ylboronic acid (250 mg, 1.33 mmol), methyl 6-bromonicotinate (260 mg, 1.21 mmol), Pd(dppf)Cl2 (90 mg, 0.12 mmol) and sodium carbonate (205 mg, 2.41 mmol) in DME/water (3 mL/1 mL) was heated to 120° C. by microwave for 1 h. Then the mixture was partitioned with water (10 mL) and EA (20 mL). The precipitate was filtered off. The organic phase was separated, washed with brine (15 mL), dried over Na2SO4 and concentrated to afford product (crude, 380 mg) as a brown oil.

1. customThen the mixture was partitioned with water (10 mL) and EA (20 mL)
2. filtrationThe precipitate was filtered off
3. customThe organic phase was separated
4. washwashed with brine (15 mL)
5. dry with materialdried over Na2SO4
6. concentrationconcentrated
7. customto afford product (crude, 380 mg) as a brown oil