Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Simtuzumab | HCID 17750227 | — |
| Reactant | HCID 67974363 | HCID 67974363 | — |
| Product | HCID 67974748 | HCID 67974748 | 70% |
Reaction Steps
Followed the coupling procedure described in Step 1 of Example 20, where the starting materials were 3-fluoro-2-iodo-6-methoxynaphthalene (Intermediate 6) and 4-carboxy-2-chlorophenylboronic acid and wherein the reaction was heated to 90° C. for 3 hours. The desired product (380 mg, yield 70%) was isolated as a solid after workup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09249132B2 |
|---|
| Source dataset | uspto-grants-2016_02 |
|---|
| ORD ID | ord-3d821115e7704547ab6caa29324ba42d |
|---|
| Source note | uspto-grants-2016_02 |
|---|
