4-Methoxycarbonylphenylboronic acid → HCID 67974998, compound

HRID 1771464Notes

Reaction equation

HRID 1771464 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14](Br)[C:13]([O:20][CH2:21][O:22][CH3:23])=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:25][C:26]([C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1)=[O:27]>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14]([C:31]1[CH:32]=[CH:33][C:28]([C:26]([OH:27])=[O:25])=[CH:29][CH:30]=1)[C:13]([O:20][CH2:21][O:22][CH3:23])=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27343694-Methoxycarbonylphenylboronic acidHCID 67974776HCID 67974776, compound2×

Product 1

HCID 67974998HCID 67974998, compoundYield 72%

Conditions

Temperature
90 °C

Procedure

Followed the coupling procedure described in Step 1 of Example 20, where the starting materials were 6-(benzyloxy)-2-bromo-3-(methoxymethoxy)naphthalene (Intermediate 11) and 4-methoxycarbonylphenylboronic acid and where the reaction was stirred at 90° C. for 3 hours. The desired product (1.30 g, yield 72%) was obtained as an off-white solid.

Sources & evidence

ORD record
ord-80f815c4353e463297b1ed037ef14378
Source dataset
uspto-grants-2016_02
Patent number
US09249132B2

Reaction notes

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