Nitrogen → HCID 67974825, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ZnCl2 (1.32 g, 9.68 mmol) in anhydrous THF (20 mL) was added MeMgCl (1.6 mL, 4.80 mmol, 3M in THF) and the mixture was stirred at under N2 atmosphere at 10° C. for 1 hour. Then methyl 4-(6-(benzyloxy)-3-(((trifluoromethyl)sulfonyl)oxy)naphthalen-2-yl)benzoate (500 mg, 0.968 mmol) and Pd(PPh3)4 (100 mg, 0.0865 mmol) was added and the mixture was stirred at 60° C. under N2 atmosphere for 3 hours. After an aqueous/EtOAc workup, the residue was purified by silica gel column (PE/EtOAc=40/1) to give the product (250 mg, yield 68%) as an off-white solid.

Provenance & Evidence