Triethylamine → 4-Methyl-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]benzamide

Participants

Reaction Steps

4-p-Tolyl-thiazol-2-ylamine (38.1 mg, 0.200 mmol) and 4-methyl-benzoyl chloride (30.5 mg, 0.200 mmol) were dissolved in 1,4-dioxane (2 mL) containing triethylamine (84.1 μL, 0.600 mmol). The reaction mixture was stirred overnight at room temperature. The crude product was filtered, evaporated to dryness, dissolved in 1 mL of dimethylsulfoxide and purified by reverse-phase preparative liquid chromatography (13.5 mg, 0.0438, 21.9%). ESI-MS m/z calc. 308.1, found 309.0 (M+1)+ Retention time 3.72 minutes.

Provenance & Evidence