HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Cyclopropyl-N'-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea → HCID 86691158, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Cyclopropyl-N'-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea | HCID 44119149 | — |
| Reactant | (S)-4-(6-(5-fluoropyridin-3-yl)-2-(methylthio)pyrimidin-4-yl)-3-methylmorpholine | HCID 67382782 | — |
| Reactant | (S)-4-(4,6-Dichloropyrimidin-2-yl)-3-methylmorpholine | HCID 72942068 | — |
| Product | HCID 86691158 | HCID 86691158 | 31% |
Reaction Steps
Method as described for intermediate 5 using (S)-4-(4,6-dichloropyrimidin-2-yl)-3-methylmorpholine (intermediate 1B) and 4-(3-cyclopropylureido)phenyl boronic acid pinacol ester to afford an orange solid (400 mg, 31%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249129B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-7a8dc2ce0e4a40079ba5ab11cd366817 |
| Source note | uspto-grants-2016_02 |