HRID1771540

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734620

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

C12H18BNO2

结构：CSc1nc(-c2cncc(F)c2)cc(N2CCOC[C@@H]2C)n1

HCID67382782

未命名化合物

结构：C[C@H]1COCCN1c1nc(Cl)cc(-c2cc(F)ccc2S(C)(=O)=O)n1

HCID86691148

未命名化合物

2 次

PRODUCTS

生成物

结构：C[C@H]1COCCN1c1nc(-c2ccc(N)cc2)cc(-c2cc(F)ccc2S(C)(=O)=O)n1

HCID67382314

未命名化合物

收率 58%

PROCEDURE

实验过程

Method as described for intermediate 5 using (S)-4-(4-chloro-6-(5-fluoro-2-(methylsulfonyl)phenyl)pyrimidin-2-yl)-3-methylmorpholine (intermediate 16) (451 mg, 1.17 mmol) and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (256 mg, 1.17 mmol). The mixture was purified using flash chromatography (30-100% EtOAc in petroleum ether 40-60) to afford the title compound (298 mg, 58%)

WORKUP

后处理

customThe mixture was purified