HRID1771553

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)OB(c2ccc(NC(=O)NC3CC3)cc2)OC1(C)C

HCID44119149

N-Cyclopropyl-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea

C16H23BN2O3

结构：CSc1nc(-c2cncc(F)c2)cc(N2CCOC[C@@H]2C)n1

HCID67382782

未命名化合物

HCID87379247

未命名化合物

2 次

PRODUCTS

生成物

结构：C[C@H]1COCCN1c1nccc(-c2ccc(NC(=O)NC3CC3)cc2)n1

HCID53380860

未命名化合物

收率 66%

PROCEDURE

实验过程

Method as described for intermediate 5 using (S)-4-(4-chloropyrimidin-2-yl)-3-methylmorpholine (intermediate 15) and 4-(3-cyclopropylureido)phenyl boronic acid pinacol ester. Material was purified using flash chromatography (20-90% EtOAc in petroleum ether 40-60) to afford a light pink solid (130 mg, 66%).

WORKUP

后处理

customMaterial was purified