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HRID1771554

反应详情

EQUATION

反应方程式

HRID 1771554 的结构方程式

REACTANTS

反应物

3
结构：CC1(C)OB(c2ccc(NC(=O)NC3CC3)cc2)OC1(C)C
HCID44119149

N-Cyclopropyl-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea

C16H23BN2O3

结构：CSc1nc(-c2cncc(F)c2)cc(N2CCOC[C@@H]2C)n1
HCID67382782

未命名化合物

结构：C[C@H]1COCCN1c1nc(Cl)cc(-c2cc(F)ccc2S(C)(=O)=O)n1
HCID86691148

未命名化合物

2 次

PRODUCTS

生成物

1
结构：C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3CC3)cc2)cc(-c2cc(F)ccc2S(C)(=O)=O)n1
HCID53380861

未命名化合物

PROCEDURE

实验过程

Method as described for intermediate 5 using (S)-4-(4-chloro-6-(5-fluoro-2-(methylsulfonyl)phenyl)pyrimidin-2-yl)-3-methylmorpholine (intermediate 16) and 4-(3-cyclopropylureido)phenyl boronic acid pinacol ester. Material was purified by prep HPLC (low pH) to afford a brown solid, (43 mg, 17%).

WORKUP

后处理

  1. customMaterial was purified by prep HPLC (low pH)
  2. customto afford a brown solid, (43 mg, 17%)