HRID1771557

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)OB(c2ccc(NC(=O)NCCO)cc2)OC1(C)C

HCID44607354

未命名化合物

2 次

结构：CSc1nc(-c2cncc(F)c2)cc(N2CCOC[C@@H]2C)n1

HCID67382782

未命名化合物

HCID86691152

未命名化合物

2 次

PRODUCTS

生成物

结构：C[C@H]1COCCN1c1cc(-c2ccccn2)nc(-c2ccc(NC(=O)NCCO)cc2)n1

HCID53379443

未命名化合物

收率 64%

PROCEDURE

实验过程

Method as described for intermediate 5 using (S)-4-(2-chloro-6-(pyridin-2-yl)pyrimidin-4-yl)-3-methylmorpholine (intermediate 21) and 1-(2-hydroxyethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (intermediate 18). Material was purified by prep HPLC (low pH) to afford a grey solid. Further purification was achieved using an SCX-2 cartridge to afford a grey solid (122 mg, 64%).

WORKUP

后处理

customMaterial was purified by prep HPLC (low pH)
customto afford a grey solid
customFurther purification