Ethyl isocyanate → HCID 53379666, compound

Participants

Reaction Steps

4-(2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyrimidin-4-yl)aniline (intermediate 26) (100 mg, 0.354 mmol) was stirred with triethylamine (74 μl, 0.532 mmol) and ethylisocyanate (42 μl, 0.531 mmol) in DCM (2 ml) overnight. The reaction mixture was concentrated in vacuo and then purified by prep HPLC at low pH. (24 mg, 19%)

Provenance & Evidence