3-Amino-1-propanol → (S)-1-(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-(3-hydroxypropyl)urea

Participants

Reaction Steps

Method as described for example 58 using (S)-phenyl(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)carbamate (intermediate 32) (140 mg, 0.25 mmol) and 3-aminopropan-1-ol (28 mg, 0.375 mmol). The reaction mixture was purified by prep HPLC at low pH to afford the title compound as a yellow solid. (29 mg, 21%)

Provenance & Evidence