HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 66678959, compound → (S)-4-(6-chloro-2-(methylthio)pyrimidin-4-yl)-3-methylmorpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 66678959 | HCID 66678959 | — |
| Reactant | (S)-4-(6-(5-fluoropyridin-3-yl)-2-(methylthio)pyrimidin-4-yl)-3-methylmorpholine | HCID 67382782 | — |
| Reactant | (S)-4-(2-chloro-6-(5-fluoropyridin-3-yl)pyrimidin-4-yl)-3-methylmorpholine | HCID 86691143 | — |
| Product | (S)-4-(6-chloro-2-(methylthio)pyrimidin-4-yl)-3-methylmorpholine | HCID 86691142 | 25% |
Reaction Steps
Method as described for intermediate 5 using (S)-4-(2-chloro-6-(5-fluoropyridin-3-yl)pyrimidin-4-yl)-3-methylmorpholine (intermediate 7) and 1-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(2-hydroxyethyl)urea (intermediate 13). Material was purified by prep HPLC (high pH) to afford a brown solid, (4 1 mg, 25%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249129B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-1ba09c1fcccc47da9453e5ccca97a784 |
| Source note | uspto-grants-2016_02 |