HRID1771574

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CSc1nc(-c2cncc(F)c2)cc(N2CCOC[C@@H]2C)n1

HCID67382782

未命名化合物

结构：CC1(C)OB(c2ccc(NC(=O)NCCF)cc2F)OC1(C)C

HCID86663172

N-(2-Fluoroethyl)-N′-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea

C15H21BF2N2O3

2 次

结构：C[C@H]1COCCN1c1cc(-c2cncc(F)c2)nc(Cl)n1

HCID86691143

未命名化合物

2 次

PRODUCTS

生成物

结构：C[C@H]1COCCN1c1cc(-c2cncc(F)c2)nc(-c2ccc(NC(=O)NCCF)cc2F)n1

HCID53379862

未命名化合物

PROCEDURE

实验过程

Method as described for intermediate 5 using(S)-4-(2-chloro-6-(5-fluoropyridin-3-yl)pyrimidin-4-yl)-3-methylmorpholine (intermediate 7) and 1-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(2-fluoroethyl)urea (intermediate 14). Material was purified by prep HPLC (high pH) followed by purification using a TsOH cartridge (500 mg) to afford a brown solid, (10 mg, 6%).

WORKUP

后处理

customMaterial was purified by prep HPLC (high pH)
customfollowed by purification
customto afford a brown solid, (10 mg, 6%)