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HRID1771575

反应详情

EQUATION

反应方程式

HRID 1771575 的结构方程式

REACTANTS

反应物

3
结构：CSc1nc(-c2cncc(F)c2)cc(N2CCOC[C@@H]2C)n1
HCID67382782

未命名化合物

结构：CC1(C)OB(c2ccc(NC(=O)NCCF)cc2F)OC1(C)C
HCID86663172

N-(2-Fluoroethyl)-N′-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea

C15H21BF2N2O3

2 次

结构：C[C@H]1COCCN1c1cc(-c2cc(F)ccc2S(C)(=O)=O)nc(Cl)n1
HCID86691149

未命名化合物

2 次

PRODUCTS

生成物

1
结构：C[C@H]1COCCN1c1cc(-c2cc(F)ccc2S(C)(=O)=O)nc(-c2ccc(NC(=O)NCCF)cc2F)n1
HCID53379863

未命名化合物

PROCEDURE

实验过程

Method as described for intermediate 5 using (S)-4-(2-chloro-6-(5-fluoro-2-(methylsulfonyl)phenyl)pyrimidin-4-yl)-3-methylmorpholine (intermediate 10) and 1-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(2-fluoroethyl)urea (intermediate 14). Material was purified by using a TsOH cartridge (500 mg) followed by prep HPLC (low pH) to afford a white solid, (26 mg, 14%).

WORKUP

后处理

  1. customMaterial was purified
  2. customto afford a white solid, (26 mg, 14%)