1-Amino-2-propanol → 1-(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-((S)-3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-(2-hydroxypropyl)urea

Participants

Reaction Steps

Method as described for example 58 using (S)-phenyl(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)carbamate (intermediate 32) (100 mg, 0.18 mmol) and 1-aminopropan-2-ol (20 mg, 0.27 mmol). The reaction mixture was purified by prep HPLC at low pH to afford the title compound as a yellow solid. (46 mg, 48%)

Provenance & Evidence