(R)-(-)-2-Amino-1-propanol → 1-(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-((S)-3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-((R)-1-hydroxypropan-2-yl)urea

Participants

Reaction Steps

Method as described for example 58 using intermediate 32 (100 mg, 0.18 mmol) and (R)-2-aminopropan-1-ol (20 mg, 0.267 mmol). The reaction mixture was purified by prep HPLC at low pH to afford the title compound. (59 mg, 61%)

Provenance & Evidence