HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-Aminocyclobutyl)methanol → (S)-1-(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-(1-(hydroxymethyl)cyclobutyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-Aminocyclobutyl)methanol | HCID 21624254 | — |
| Reactant | (S)-phenyl(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)carbamate | HCID 89717157 | — |
| Product | (S)-1-(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-(1-(hydroxymethyl)cyclobutyl)urea | HCID 67382639 | — |
Reaction Steps
Method as described for example 58 using intermediate 32 (100 mg, 0.18 mmol) and (1-aminocyclobutyl)methanol (27 mg, 0.267 mmol). The reaction mixture was purified by prep HPLC at low pH to afford the title compound. (54 mg, 53%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249129B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-b183e44792664993bcd2fc41ab1b756e |
| Source note | uspto-grants-2016_02 |