HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S,2S)-2-Aminocyclopentanol → 1-(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-((S)-3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-((1S,2S)-2-hydroxycyclopentyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S,2S)-2-Aminocyclopentanol | HCID 11571787 | — |
| Reactant | (S)-phenyl(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)carbamate | HCID 89717157 | — |
| Product | 1-(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-((S)-3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-((1S,2S)-2-hydroxycyclopentyl)urea | HCID 86691156 | — |
Reaction Steps
Method as described for example 58 using intermediate 32 (100 mg, 0.18 mmol) and (1S,2S)-2-aminocyclopentanol (27 mg, 0.267 mmol). The reaction mixture was purified by prep HPLC at low pH to afford the title compound. (50 mg, 49%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249129B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-2cd84d47e06a4b6098d66eceaa5e0229 |
| Source note | uspto-grants-2016_02 |