反应详情

温度

60 °C

To a solution of 2-fluoro-5-(3-fluorophenyl)-N-(3-hydroxy-2,6-dimethyl-phenyl)benzamide (400 mg, 1.13 mmol, 1.0 eq) in THF under N2 was added dropwise a solution of BH3 (5.65 mL, 1M in THF, 5.65 mmol, 5.0 eq). The reaction mixture was heated to 60° C. and stirred under N2 for 3 h. After cooling, the resulting mixture was quenched by addition of 1 M HCl and water and the aqueous layer extracted with EtOAc. The organic extract was dried (Na2SO4), filtered, evaporated in vacuo and purified by column chromatography (EtOAc:petroleum ether, 0:1 to 1:4) to give the title product as yellow oil (340 mg, 89%).

1. temperatureAfter cooling
2. customthe resulting mixture was quenched by addition of 1 M HCl and water
3. extractionthe aqueous layer extracted with EtOAc
4. extractionThe organic extract
5. dry with materialwas dried (Na2SO4)
6. filtrationfiltered
7. customevaporated in vacuo
8. custompurified by column chromatography (EtOAc:petroleum ether, 0:1 to 1:4)