HCID 89443857, compound → 3-[[2-Chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-di fluoro-phenol

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-chloro-N-(2,6-difluoro-3-hydroxy-phenyl)-5-(3-fluorophenyl)benzamide (150 mg, 0.34 mmol, 1.0 eq) in THF (3 mL) was added a solution of BH3 (1M in THF, 1.72 mL, 1.72 mmol, 5.0 eq). The reaction was heated at 60° C. for 3 h, then quenched by addition of 1M HCl. The aqueous layer was extracted with EtOAc and the organic extract was washed with water and brine, dried (Na2SO4) filtered and evaporated in vacuo. The residue obtained was purified by flash chromatography (petroleum ether:EtOAc, 100:1 to 30:1) to give the title compound as a colourless oil (128 mg, 89%).

Provenance & Evidence