Ribociclib → 7-cyclopentyl-2-{5-[4-(piperidine-1-carbonyl)-piperazin-1-yl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide
Reaction equation
[CH3:1][N:2]([C:3](=[O:4])[c:5]1[cH:6][c:7]2[c:8]([n:9][c:10]([NH:13][c:14]3[n:15][cH:16][c:17]([N:20]4[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]4)[cH:18][cH:19]3)[n:11][cH:12]2)[n:26]1[CH:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1)[CH3:32].[N:33]1([C:39](=[O:40])[Br:41])[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]1>>[CH3:1][N:2]([C:3](=[O:4])[c:5]1[cH:6][c:7]2[c:8]([n:9][c:10]([NH:13][c:14]3[n:15][cH:16][c:17]([N:20]4[CH2:21][CH2:22][N:23]([C:39]([N:33]5[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]5)=[O:40])[CH2:24][CH2:25]4)[cH:18][cH:19]3)[n:11][cH:12]2)[n:26]1[CH:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1)[CH3:32]Participants
3
Sources & evidence
- ORD record
- ord-696288310a194f888f5d5529643e8979
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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