HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Fluoro-5-(3-fluorophenyl)-2-methyl-3-nitro-benzene → 3-Fluoro-5-(3-fluorophenyl)-2-methyl-aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Fluoro-5-(3-fluorophenyl)-2-methyl-3-nitro-benzene | HCID 89445455 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Fluoro-5-(3-fluorophenyl)-2-methyl-aniline | HCID 89445331 | 44% |
Reaction Steps
A solution of 1-fluoro-5-(3-fluorophenyl)-2-methyl-3-nitro-benzene (4.0 g, 16.0 mmol, 1.0 eq) in EtOH (80 mL) was added to Pd/C (10%, 0.8 g) and the mixture stirred under hydrogen for 48 h. The catalyst was removed by filtration through celite and the compound purified by silica gel chromatography (petroleum ether:EtOAc, 20:1 to 10:1) to give the title compound as a white solid (1.54 g, 44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249085B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-9171a96f95074d139f59f33396152dac |
| Source note | uspto-grants-2016_02 |