反应详情

A solution of isopropyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate (II(d)) (0.2 g, 0.45 mmol, 1.0 eq) in ethylamine (6 mL, 60-70% aqueous solution) was stirred at 100° C. overnight in a sealed tube. The reaction mixture was then cooled to room temperature and poured into water. The mixture was extracted with EtOAc and the combined organic extracts were washed with water and brine, dried (Na2SO4), filtered and evaporated in vacuo. The residue was purified by column chromatography (EtOAc:petroleum ether, 1:20 to 1:4, v/v) to give the title compound as a white solid (0.15 g, 80%).

1. extractionThe mixture was extracted with EtOAc
2. washthe combined organic extracts were washed with water and brine
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. customevaporated in vacuo
6. customThe residue was purified by column chromatography (EtOAc:petroleum ether, 1:20 to 1:4, v/v)