Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 71272395 | HCID 71272395 | — |
| Reactant | HCID 89415351 | HCID 89415351 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 71272247 | HCID 71272247 | 70% |
Reaction Steps
Cul (19 mg), Pd(OAc)2 (22 mg) and Cs2CO3 (1.27 g) are added to a degassed solution of 4-chloro-2-(4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]-pyridine (628 mg), N-(2-ethynylphenyl)-N-methylmethanesulfonamide (450 mg) in 1,4-dioxane (10 ml), and the mixture is stirred at 100° C. for 5 h. Conventional work-up and purification gives the title compound in 70% yield (663 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09249140B2 |
|---|
| Source dataset | uspto-grants-2016_02 |
|---|
| ORD ID | ord-d8b0e72f0f0948bb9db017eaab54b538 |
|---|
| Source note | uspto-grants-2016_02 |
|---|
