Methanol → Methyl (chlorosulfonyl)acetate

HRID 1771860Notes

Reaction equation

HRID 1771860 reaction equation
[Cl:1][S:2]([CH2:5][C:6](Cl)=[O:7])(=[O:4])=[O:3].[CH3:9][OH:10]>CCOCC>[CH3:9][O:10][C:6](=[O:7])[CH2:5][S:2]([Cl:1])(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 887MethanolHCID 77642(Chlorosulphonyl)acetyl chloride

Product 1

HCID 11435213Methyl (chlorosulfonyl)acetate

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of chlorosulfonylacetyl chloride (419 μL, 3.955 mmol, 1 eq.) in Et2O (4 mL), at 0° C. was added MeOH (160 μL, 3.955 mmol, 1 eq.). The reaction mixture is stirred at 0° C. for 3 h, then concentrated in vacuo to give chlorosulfonyl-acetic acid methyl ester.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-cedaa3ff960a44dc801b08b1fe751a59
Source dataset
uspto-grants-2016_02
Patent number
US09249141B2

Reaction notes

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