HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Pyrrolidineethanamine → HCID 68650132, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Pyrrolidineethanamine | HCID 1344 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 86677138 | HCID 86677138 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68650132 | HCID 68650132 | 104% |
Reaction Steps
To a solution of 4-amino-6-(methoxycarbonyl)-2-methyl-3-nitrobenzoic acid (380 mg, 1.0 mmol), HATU (114 mg, 1.0 mmol) and DIPEA (129 mg, 1.0 mmol) in THF (20 mL) was added 2-(pyrrolidin-1-yl)ethanamine (114 mg, 1.0 mmol) and stirred at RT for overnight. The reaction mixture was evaporated in vacuo and the residue was triturated with MeOH (10 mL). The yellow precipitate was isolated by filtration and dried to afford the title compound (300 mg) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249147B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-6d545715cb14467e8d70ef286300ef08 |
| Source note | uspto-grants-2016_02 |