HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → 1-(3-chloro-4-fluorophenyl)-5-(3-fluoro-5-difluoromethoxyphenyl)-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | 1-(3-chloro-4-fluorophenyl)-5-(3-fluoro-5-trifluoromethoxyphenyl)-1H-pyrazole-3-carboxylic acid | HCID 58277289 | — |
| Product | 1-(3-chloro-4-fluorophenyl)-5-(3-fluoro-5-difluoromethoxyphenyl)-1H-pyrazole-3-carboxylic acid | HCID 118236132 | — |
Reaction Steps
The intermediate product is hydrolyzed in a manner analogous to the synthesis of the compound from example 8A with 0.40 g (9.52 mmol) of lithium hydroxide monohydrate. This produces 0.34 g (88% of theoretical yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249148B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-698e5cb011734e6f9e9ccc8c6a2542a9 |
| Source note | uspto-grants-2016_02 |