HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydrazinylpyridine hydrochloride → 5-(3-Fluoro-5-difluoromethoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydrazinylpyridine hydrochloride | HCID 23143454 | — |
| Reactant | 1-(3-chloro-4-fluorophenyl)-5-(3-fluoro-5-trifluoromethoxyphenyl)-1H-pyrazole-3-carboxylic acid | HCID 58277289 | — |
| Product | 5-(3-Fluoro-5-difluoromethoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602511 | — |
Reaction Steps
590 mg (1.01 mmol) of the compound from example 4A is reacted with 161 mg (1.11 mmol) 3-pyridylhydrazine hydrochloride in a manner analogous to the synthesis of the compound from example 8A. Following hydrolysis, 150 mg (43% of theoretical yield) of the title compound is produced.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249148B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-9b5e7009b8e44b16874ddb7f94a3ecbc |
| Source note | uspto-grants-2016_02 |