HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydrazinylpyridine hydrochloride → 5-(3-Chloro-5-difluoromethoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydrazinylpyridine hydrochloride | HCID 23143454 | — |
| Reactant | 1-(3-chloro-4-fluorophenyl)-5-(3-fluoro-5-trifluoromethoxyphenyl)-1H-pyrazole-3-carboxylic acid | HCID 58277289 | — |
| Product | 5-(3-Chloro-5-difluoromethoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602483 | — |
Reaction Steps
350 mg (0.80 mmol) of the compound from example 5A is reacted with 128 mg (0.88 mmol) 3-pyridylhydrazine hydrochloride in a manner analogous to the synthesis of the compound from example 8A. Following hydrolysis, 176 mg (60% of theoretical yield) of the title compound is produced.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249148B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-e281b5c1a9eb4a0eae8ed8364e2f63d9 |
| Source note | uspto-grants-2016_02 |