HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromoisoindolin-1-one → 4-[1-(3-Chloro-4-fluoro-phenyl)-5-(3-chloro-5-fluoro-phenyl)pyrazol-3-yl]isoindolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromoisoindolin-1-one | HCID 21907509 | — |
| Reactant | 4-[1-(3-Chloro-4-fluoro-phenyl)-5-(3-chloro-5-fluoro-phenyl)pyrazol-3-yl]-2,3-dihydropyrrolo[3,4-c]pyridin-1-one | HCID 73335114 | — |
| Reactant | 4-chloro-1H,2H,3H-pyrrolo[3,4-c]pyridin-1-one | HCID 82597832 | — |
| Product | 4-[1-(3-Chloro-4-fluoro-phenyl)-5-(3-chloro-5-fluoro-phenyl)pyrazol-3-yl]isoindolin-1-one | HCID 86578830 | — |
Reaction Steps
The synthesis of the title compound is performed starting from 100 mg (0.25 mmol) of the product from step 3 of example 1 in a manner analogous to the synthesis of the compound from example 1. In step 4, instead of the compound from example 22A, 4-bromo-2,3-dihydroisoindol-1-on (63 mg, 0.30 mmol) is used. The result is 74 mg (65% of theoretical yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249148B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-5ded4bc17ac44eb9a04eb098bce167ec |
| Source note | uspto-grants-2016_02 |