HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromoisoindolin-1-one → 4-[5-[3-Chloro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]isoindolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromoisoindolin-1-one | HCID 21907509 | — |
| Reactant | 4-[5-[3-Chloro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-2,3-dihydropyrrolo[3,4-c]pyridin-1-one | HCID 73335217 | — |
| Reactant | 4-chloro-1H,2H,3H-pyrrolo[3,4-c]pyridin-1-one | HCID 82597832 | — |
| Product | 4-[5-[3-Chloro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]isoindolin-1-one | HCID 73335218 | — |
Reaction Steps
The synthesis of the title compound is performed starting from 100 mg (0.24 mmol) of the product from step 3 of the compound from example 10 in a manner analogous to step 4 of the synthesis of the compound from example 10. Instead of the compound from example 22A, 4-bromo-2,3-dihydroisoindole-1-on (61 mg, 0.29 mmol) is used. This produces 28 mg (24% of theoretical yield, 94% purity) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249148B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-421a88d15c7348a382ee262548c11655 |
| Source note | uspto-grants-2016_02 |