HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1771935Generated: November 2, 2026
Hydrochloric Acid → (3S)-piperidine-3-carboxylic acid hydrochloride
https://huagongshe.com/reaction/1771935
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (3S)-1-((tert-butoxy)carbonyl)piperidine-3-carboxylic acid | HCID 6951168 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | (3S)-piperidine-3-carboxylic acid hydrochloride | HCID 24820453 | 99.7% |
Reaction Steps
(S)-Piperidine-1,3-dicarboxylic acid 1-tert-butyl ester (20 kg, 87.2 mol) was slurried in acetic acid (189 kg) and cooled to 15° C. An excess of hydrogen chloride gas (9.6 kg) was charged and stirred for ˜4 hours to complete deprotection. The slurry was isolated and filter-cake rinsed with acetic acid (2×31.5 kg). The filter cake was then vacuum dried to obtain product (14.4 kg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09249155B2 |
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| Source dataset | uspto-grants-2016_02 |
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| ORD ID | ord-925b7b092fbe451aa4d191be1ffa875b |
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| Source note | uspto-grants-2016_02 |
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