HCID 90079870, compound → HCID 90080019, compound

Participants

Reaction Steps

To a solution of (2R,3S)-1-benzyl 4-tert-butyl 2,3-bis(cyclopropylmethyl)succinate, Intermediate S8G (0.530 g, 1.423 mmol) in MeOH (10 mL) was added 10% Pd/C (Degussa) (0.300 g, 1.423 mmol). The reaction mixture was evacuated with vacuum and filled with H2 (Repeated this for 3×). Next, the reaction mixture was stirred under H2 balloon for 1.5 h, evacuated, and filled with N2. The mixture was then filtered through CELITE®. The filtrate was concentrated to afford (2R,3S)-4-(tert-butoxy)-2,3-bis(cyclopropylmethyl)-4-oxobutanoic acid, Intermediate S8 (0.400 g, 1.417 mmol, 100% yield) as a colorless liquid. 1H NMR (400 MHz, chloroform-d) δ 2.69 (td, J=9.9, 3.7 Hz, 2H), 1.71-1.54 (m, 2H), 1.47 (s, 9H), 1.38-1.22 (m, 2H), 0.80-0.62 (m, 2H), 0.51-0.36 (m, 4H), 0.16-0.05 (m, 2H), 0.05-−0.02 (m, 2H).

Provenance & Evidence