Thionyl Chloride → 2-(Chloromethyl)-4,7-dimethylpyrazolo[1,5-a]pyrazine hydrochloride

HRID 1771978Notes

Reaction equation

HRID 1771978 reaction equation
[CH3:1][C:2]1[C:3]2[N:4]([N:9]=[C:10]([CH2:12]O)[CH:11]=2)[C:5]([CH3:8])=[CH:6][N:7]=1.S(Cl)([Cl:16])=O>>[ClH:16].[Cl:16][CH2:12][C:10]1[CH:11]=[C:3]2[C:2]([CH3:1])=[N:7][CH:6]=[C:5]([CH3:8])[N:4]2[N:9]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 68089497(4,7-Dimethylpyrazolo[1,5-a]pyrazin-2-yl)methanol

Product 1

HCID 680894742-(Chloromethyl)-4,7-dimethylpyrazolo[1,5-a]pyrazine hydrochlorideYield 100%

Procedure

A solution of (4,7-dimethylpyrazolo[1,5-a]pyrazin-2-yl)methanol (41 mg, 0.23 mmol) in thionyl chloride (2 mL) was stirred at room temperature for 5 min. The mixture was concentrated to dryness to give 53 mg (100% yield) of the title compound as a yellow solid. ESI MS: m/z 196.1 [M+H]+.

Workup

  1. concentrationThe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-f5ce3625365042f2a3b88f441b8e1532
Source dataset
uspto-grants-2016_02
Patent number
US09249162B2

Reaction notes

Loading…