HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1772029Generated: November 3, 2026
1,5-Naphthyridin-2-amine → HCID 178425985, compound
https://huagongshe.com/reaction/1772029
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,5-Naphthyridin-2-amine | HCID 589355 | — |
| Reactant | O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine | HCID 11830845 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178425985 | HCID 178425985 | 85% |
Reaction Steps
To a solution of 1,5-naphthyridin-2-amine (2.0 g, 13.8 mmol) in DCM (10 mL) was added a solution of O-(mesitylsulfonyl)hydroxylamine (8.9 g, 41.3 mmol) in DCM (20 mL) at 0° C. The mixture was stirred at 0° C. for 3 h. The precipitate was filtered and collected to give the crude product as a yellow solid (4.2 g, yield 85%). ESI MS: m/z 161 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09249162B2 |
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| Source dataset | uspto-grants-2016_02 |
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| ORD ID | ord-0999638e3ac54c7484c4f160dc4e99e6 |
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| Source note | uspto-grants-2016_02 |
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