HCID 178500432, compound → HCID 68089282, compound

HRID 1772059Notes

Reaction equation

HRID 1772059 reaction equation
[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH:5]([CH3:18])[C:6](/[N:8]=[C:9]1\[N:10]([NH2:17])[C:11]([CH3:16])=[CH:12][N:13]=[C:14]\1[CH3:15])=O>C(O)(=O)C>[CH3:16][C:11]1[N:10]2[N:17]=[C:6]([CH:5]([CH3:18])[CH2:4][C:3]([O:2][CH3:1])=[O:19])[N:8]=[C:9]2[C:14]([CH3:15])=[N:13][CH:12]=1

Participants

3

Reactant 1

HCID 178500432HCID 178500432, compound

Product 1

HCID 68089282HCID 68089282, compoundYield 111.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of (Z)-methyl-4-(1-amino-3,6-dimethylpyrazin-2(1H)-ylideneamino)-3-methyl-4-oxobutanoate (1.10 g, 4.14 mmol) in acetic acid (15 mL) was stirred at 140° C. for 2 h in a microwave reactor. The solution was evaporated to give 1.15 g of the product as a brown solid. ESI MS: m/z 248 [M+H]+.

Workup

  1. customThe solution was evaporated

Sources & evidence

ORD record
ord-84f32ef48cd449bfb82c5af123bd4a90
Source dataset
uspto-grants-2016_02
Patent number
US09249162B2

Reaction notes

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