反应详情

To 100 mL round bottom flask charged with ester 101b (230 mg, 1.04 mmol), N-bromosuccinimide (214 mg, 1.2 mmol), benzoyl peroxide (25 mg, 0.1 mmol) in benzene (5 mL). After the mixture was stirred at reflux for 4 h, H2O (10 mL) was added. The aqueous phase was extracted with CH2Cl2 (2×10 mL), and the combined organic extracts were washed with brine (10 mL), dried with Na2SO4 and concentrated. The crude 101c (287 mg, 92%) was used without further purification.

1. temperatureat reflux for 4 h
2. extractionThe aqueous phase was extracted with CH2Cl2 (2×10 mL)
3. washthe combined organic extracts were washed with brine (10 mL)
4. dry with materialdried with Na2SO4
5. concentrationconcentrated
6. customThe crude 101c (287 mg, 92%) was used without further purification