3,5-Dibromo-1-methylpyridin-2(1H)-one → HCID 178479983, compound

Participants

Reaction Steps

Using the same general procedure as Example 109c, reaction of 3-cyclopropyl-5-amino-1H-pyrazole (500 mg, 4.06 mmol) and 3,5-dibromo-1-methylpyridin-2(1H)-one (1.08 g, 4.06 mmol) afforded a 21% yield (260 mg) of 110a as an off-white solid: mp 203-204° C.; 1H NMR (500 MHz, DMSO-d6) δ 8.20 (s, 1H), 8.02 (d, 1H, J=2.5 Hz), 7.34 (d, 1H, J=2.5 Hz), 5.77 (d, 1H, J=2.1 Hz), 3.48 (s, 3H), 1.84 (m, 1H), 0.90 (m, 4H), 0.63 (m, 4H); MS (ESI+) m/z 309.0 (M+H).

Provenance & Evidence