HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(6-Nitro-pyridin-3-yl)-azetidin-3-ol → 1-(6-Aminopyridin-3-yl)azetidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(6-Nitro-pyridin-3-yl)-azetidin-3-ol | HCID 59290958 | — |
| Reactant | 1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-ylamine | HCID 59344947 | — |
| Product | 1-(6-Aminopyridin-3-yl)azetidin-3-ol | HCID 58043812 | 95.1% |
Reaction Steps
Using the same general procedure for the preparation of 119b, reduction of 120a (1.43 g, 7.32 mmol) gave a 95% yield (1.15 g) of 120b as a yellow semi-solid: 1H NMR (500 MHz, DMSO-d6) δ 7.22 (d, 1H, J=2.5 Hz), 6.69 (m, 1H), 6.35 (d, 1H, J=8.0 Hz), 5.16 (s, 1H), 4.48 (m, 1H), 3.96 (m, 2H), 3.34 (m, 2H); MS (ESI+) m/z 166.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249123B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-b90b6e90d8d444469d3d6510e68b6bbe |
| Source note | uspto-grants-2016_02 |