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HRID1772153

反应详情

EQUATION

反应方程式

HRID 1772153 的结构方程式

REACTANTS

反应物

3
结构：Cc1c(-c2cn(C)c(=O)c(Nc3ccc(C4C(=O)NCCN4C)cc3)n2)cccc1N1Cc2cc(C(C)(C)C)sc2C1=O
HCID56928442

未命名化合物

结构：Cn1cc(Br)cc(Nc2ccncn2)c1=O
HCID58044094

5-Bromo-1-methyl-3-(4-pyrimidinylamino)-2(1H)-pyridinone

C10H9BrN4O

结构：CC(=O)OCc1c(B2OC(C)(C)C(C)(C)O2)cccc1N1Cc2cc(N(C)C)ccc2C1=O
HCID86699872

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)c1ccc2c(c1)CN(c1cccc(-c3cc(Nc4ccncn4)c(=O)n(C)c3)c1CO)C2=O
HCID56928860

未命名化合物

收率 33.6%

PROCEDURE

实验过程

Using the same general procedure as described for the preparation of 104, reaction of 123e (400 mg, 0.890 mmol) with 107a (207 mg, 0.740 mmol) followed by a hydrolysis gave a 28% yield (120 mg) of 124 as a white solid: mp 206-208° C.; 1H NMR (500 MHz, DMSO-d6) δ 9.17 (s, 1H), 8.73 (d, 1H, J=2.0 Hz), 8.65 (s, 1H), 8.30 (d, 1H, J=6.0 Hz), 7.57 (d, 1H, J=8.5 Hz), 7.55 (d, 1H, J=2.5 Hz), 7.49 (t, 1H, J=2.5 Hz), 7.43 (dd, 1H, J=8.0, 1.5 Hz), 7.37 (dd, 1H, J=8.0, 1.5 Hz), 7.31 (dd, 1H, J=6.0, 1.5 Hz), 6.88-6.85 (m, 2H), 4.94 (t, 1H, J=4.5 Hz), 4.86 (s, 2H), 4.32 (d, 2H, J=4.5 Hz), 3.61 (s, 3H), 3.04 (s, 6H); MS (ESI+) m/z 483.2 (M+H).