HCID 66609034, compound → HCID 66609718, compound

HRID 1772159Notes

Reaction equation

[C:1]([C:5]1[S:6][C:7]([CH2:13][NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]3[CH:26]=[C:25]([NH:27][C:28]4[CH:33]=[CH:32][N:31]=[CH:30][N:29]=4)[C:24](=[O:34])[N:23]([CH3:35])[CH:22]=3)[C:16]=2[CH2:36][O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:40])[CH3:39])=[C:8]([C:10]([OH:12])=[O:11])[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[C:45](C1SC(CNC2C=CC=C(C3C=C(NC4NN=C(C5CC5)C=4)C(=O)N(C)C=3)C=2CO[Si](C(C)(C)C)(C)C)=C(C(OC)=O)N=1)(C)(C)C>>[C:1]([C:5]1[S:6][C:7]([CH2:13][NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]3[CH:26]=[C:25]([NH:27][C:28]4[CH:33]=[CH:32][N:31]=[CH:30][N:29]=4)[C:24](=[O:34])[N:23]([CH3:35])[CH:22]=3)[C:16]=2[CH2:36][O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:40])[CH3:39])=[C:8]([C:10]([O:12][CH3:45])=[O:11])[N:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 66609034HCID 66609034, compound

HCID 178499089HCID 178499089, compound

Product 1

HCID 66609718HCID 66609718, compound

Procedure

Following the procedures as described for compound 125e and starting with methyl 2-tert-butyl-5-((2-((tert-butyldimethylsilyloxy)methyl)-3-(5-(3-cyclopropyl-1H-pyrazol-5-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenylamino)-methyl)thiazole-4-carboxylate, 125d was obtained as a yellow solid (crude). LCMS: (M+H)+ 663.

Sources & evidence

ORD record: ord-10450a9057e742c2b9ca61bc4a67ce45
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09249123B2

Reaction notes

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